This mahabhoota evolves last in the series. Its main sense attrinute is the sense of smell and its main property is Kharatwa (roughness). All these are the basic building blocks of creation. With the help of these simple building blocks the entire complicated universe with its living and non-living matter is created. In ayurveda besides these panchamahabhoota the Dik (disha, direction), Kala (time), Atma (Soul) and Mana (psyche) are also considered responsible for the creation of living beings.

Panchbhautic Chikitsa Siddhant
Ayurveda believes that all matter in the universe including medicines are made up of Panchmahabhoota, i.e. Akasha, Vayu, Agni, Jala and Prithvi. At the sam time ayurveda also believes in living beings are made up of Dosha, Dhatu and Mala also.

To maintain health the homeostasis of the constituent panchamahabhoota is important. Deviation from the basic constitution (prakruti) leads to disease (vikruti) and to bring back prakruti from vikruti what is required are active efforts in the form of chikitsa (medication).